Age dependence of tumor genetics in unfavorable neuroblastoma: arrayCGH profiles of 34 consecutive cases, using a Swedish 25-year neuroblastoma cohort for validation

An Unfavorable Metastatic Site at Initial Diagnosis in a 2-year-old Boy with Neuroblastoma

Neuroblastoma (NB) is considered one of the malignant tumors of the nervous system which originates from primordial neural crest cell and is known as the most common extra-cranial solid tumor in childhood. This tumor which is often intra-abdominal, metastases in various sites including the skull, long bones, liver, bone marrow and lymph nodes, but lung metastasis at initial diagnosis is rare (0...

Bone Involvement in Neuroblastoma

The genetics of splicing in neuroblastoma.

UNLABELLED Regulation of mRNA splicing, a critical and tightly regulated cellular function, underlies the majority of proteomic diversity and is frequently disrupted in disease. Using an integrative genomics approach, we combined both genomic data and exon-level transcriptome data in two somatic tissues (cerebella and peripheral ganglia) from a transgenic mouse model of neuroblastoma, a tumor t...

Retroperitoneal Anaplastic Neuroblastoma in a 3-Year-Old Female: A Rare Case Report

Neuroblastoma is the most common extracranial solid tumor in childhood. In different classification of neuroblastomas, a subset of undifferentiated or poorly differentiated tumors with bizarre histological features has been mentioned. A 3-year-old girl presented with abdominal pain. Her haematological and biochemical parameters were normal except her urinary vanelylmandelic acid level was elevat...

Molecular Markers in Neuroblastoma

Neuroblastoma, one of the common malignant childhood tumors, arises from neuroblast cells derived from theneural crest and destined for the adrenal medulla and the sympathetic nervous system and shows remarkable biologicalheterogeneity, resulting in favorable or unfavorable outcomes. Some tumors make rapid progress with a fataloutcome. In other instances, the tumors regress spontaneously in inf...